The Red Queen is a powdery like substance that once inhaled or consumed can cause the user to hallucinate and go through a drug trip, which will force them to confront their deepest regrets in their mind.
Mad hypnotist Jervis Tetch came under possession of the drug which he planned to use as part of his plan to get back at Gotham City in retaliation for the death of his sister Alice. He retrieved her body and planned to use her tainted blood to create a type of potion to use on the powerful people of the city and transform them into 'monsters'.
Tetch used the Red Queen on his enemy Jim Gordon, whom he blamed for the death of his sister. Under the drug Gordon went deeper into his mind, before facing the death of his father and being given advice on controlling his darker side and doing good. With the help of Doctor Mario Calvi Gordon managed to fight the substance with only a mere minute to spare before he expired.
Tetch was in the process of getting the powerful people of Gotham to drink wine laced with the drug, one of them being Mayor Oswald Cobblepot. However the GCPD gatecrashed it and arrested Tetch. Despite his plan being foiled, he still found delight in the fact Captain Nathaniel Barnes was poisoned by Alice's blood and transforming.
- Jim Gordon (unwillingly)
- The name of the drug is a clear nod to the character of the same name from the Lewis Carroll fantasy novel Through the Looking-Glass, which is in reference to Jervis Tetch/Mad Hatter's obsession with Alice's Adventures in Wonderland in the mainstream DC Comics.